Recently Scientist from USA, UK and Germany reported the
genomic variation in mouse and its effect on
phenotypes and
gene regulation. They reported genome sequences of 17
inbred strains of laboratory mice and identified almost ten times more
variants than previously known. By identifying candidate functional variants at 718
quantitative trait loci, scientists showed that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism.
Research outcomes are published in latest issue of
Nature
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