The combination of next generation sequencing with a comparative genomics approach appears particularly promising towards yielding detailed insights into issues related to evolutionary biology. Very recently canadian scientists applied this strategy to investigate patterns of nucleotide substitutions in five species of the salmonid family (Salmo salar, Onchorynchus mykiss, Salvelinus fontinalis, Salvelinus namaycush, Coregonus clupeaformis) and compare this information with other fishes (Esox lucius, Danio rerio) for which genome information is available in order to infer the role of natural selection on the evolution of protein coding genes.
Results of the study warrant further investigation in regards to the putative role of positive selection in the process of adaptive divergence in salmonids. Findings of this study are published in the latest issue of Molecular Biology and Evolution.
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