Recently scientists from USA and Germany have constructed a genome-wide fish metabolic network model, MetaFishNet. The recent completion of genome sequencing of five fish species (Danio. rerio, Oryzias latipes, Tetraodon rubripes, T. nigroviridis and Gasterosteus aculeatus) has paved the way for constructing a genome-wide fish metabolic network model.
All metabolic enzymes have been identified from complete genomes by sequence analysis, compounds were then be associated with enzymatic activities and a metabolic network was constructed by linking these compounds and enzymes. The first and primary role of MetaFishNet model is a bioinformatic tool for analyzing high throughput expression data, as well as a framework for future systems studies. This genome-wide model offers a significant expansion of the KEGG zebrafish model. MetaFishNet can be used compare fish and human metabolism to identify the most and least conserved pathways.
This study is published in the November, 2010 issue of Genome Biology.
http://genomebiology.com/2010/11/11/R115
No comments:
Post a Comment