Researchers led by Stephen Ekker, a molecular biologist at the Mayo Clinic in Rochester, Minnesota, have for the first time made custom
changes to parts of the zebrafish (Danio rerio) genome, using
artificial enzymes to cut portions of DNA out of targeted positions in a
gene sequence, and replace them with synthetic DNA. The work is
published in Nature. Ekker and his colleagues are the first to use artificial TALENs for genome editing in live zebra fish larvae. TALENs have the potential to work on any DNA sequence and cause permanent modifications. They also allow faster analysis of
induced mutations — in some cases, the team found, it is possible to
observe effects in the injected larvae immediately.
Read more: Nature-doi:10.1038/nature.2012.11463
